Just guts feeling: size matters. Even if 2x xx diameter might have the same surface area (or moved air volume) than 1x yy (or to show my point, 20x 5 inch woofers same as (haven't done the math) 1x 18" woofer), I just don't think a bunch of 5" can naturally produce the 50 Hz and below (down to 20) that an 18" can. Therefor IMO, 1 big is better than 2 small.
This is coming from years of listening to towers with sidefiring 10", plus 2 active 12". Then I got my first REAL SUB (in a humongous vented box, driven by an ICE sub amp), and the world changed. I ran the towers as 'small' speakers in my 5.1 system, and now the tiny (5x80W) receiver sounded SO much better.
I am now using an 18" in a sealed 4.5ft3 enclosure, driven by the same B&O ICE design amp. Just LOVE it. Once you heard real SUB (the stuff "down there") there is no going back. My Nautilus 804 are said to have great lows. And they do. But so much better if aided by the 18 incher.