Are you talking about something ON your DESK, or IN a room like small office?
In any case, I would solve sitting center/great imaging 1st, then what size, then quality. On desk, self powered can makes sense, unless you want tube sound, then a low powered tube amp (I use 10 wpc) to keep heat down.
I don’t like ports, if so, front not side or rear, gives better options if you move them.
I was using headphone out for years, until using USB out to DAC to amp was recommended here. Far better.
I use integrated audio from Intel Motherboard, rather than separate audio or av board, too avoid extra fan noise.