I have a pair of Buchardt Audio S400 MK II speakers, that are designed with the woofer top/tweeter below. With my speaker stands the tweeter is at ear level. I did try the upside down with the tweeters at ear level, and the soundstage was off…..didn’t try messing around much more, moved them back pretty quickly.
I do use “drum dampener silicone pads” that Mads Buchardt suggested in an email, that do make a very noticeable improvement