Dual speaker system

It’s ok to make a decision, however: having two pairs of speakers in the same room, is not best practice, the cones of the inactive speakers react to the output of the speakers playing. Perhaps make sound wave absorbing/blocking covers that cover one pair while playing the other pair.

I’ve done the opposite: 3 optional amps into one set of speakers: wbt tightening banana plugs end of 3 pairs of color coded speaker wires optionally connected to pigtail connector of speakers’ wire, (connecting joint located waist high so I could reach/change with ease. McIntosh SS MC2250 (250 wpc)/Fisher 500C Tube Receiver (35 wpc)/Fisher 80AZ Mono Tube Amps (30 wpc). Everyone always chose tubes over SS. And, I have some content in 3 formats: CD/LP/R2R Tape, i.e. Sgt. Peppers; Original Moody Blues; Inna Gadda Da Vida ...

even though the R2R specs are the lowest quality signal to noise ratio, and tape hiss can be heard between tracks and quiet passages, everyone picks LP over CD and R2R over LP: tubes/R2R is my best sounding combo!

It's the improved degree of Involvement that occurs, not cleaner specs.

@elliottbnewcombjr now we are talking! So your first point is important  — does a second set of speakers affect the primary speakers? Looks like the answer is yes. 
 

My primary speakers are SF Amati paired with Mc 601s and I was thinking of a completely different second amp/speaker combo, but what if I added a Mc275 tube amp to the Amati and manually switched between the amps. That would be fun. Have you considered a speaker cable switch? I’d worry the switch would degrade SQ though.

@kota1 all same room!

@cptrips I”d be interested to hear more about how you are daisy chaining. I love the idea of two amps and two speakers and being able to switch between them all for different combinations 

To avoid a switch, I left a run of speaker cable from my speakers to a hook on the wall behind them that I could reach easily. Next, pull up the desired set of speaker wires from the desired amp (different colored tape on wire ends) and a spot of color tape on the front of each amp for feeble minded reminder.

wbt type bananas with set screws and center pin tightening

https://www.parts-express.com/Stacking-Banana-Plug-with-Dual-Set-Screws-Poly-Carbonate-Sh-091-3608?quantity=1

when using spades (connection at speakers/amps, I like the two set screw type

https://www.parts-express.com/5-16-Spade-Terminal-with-Dual-Set-Screws-and-Poly-Carbonate-091-3606?quantity=1

I have a similar situation and setup but (perhaps) for different reasons.

In my dedicated room I have my system on one side of the rack and a system for the family on the other side.  That way they don't mess with my stuff and dont use my speakers for movies.

My side Stream+SACD+DVDA-Allnic Pre-Manley+Threshold amps-Infinity IRS Beta

Their side Heos/stream-Denon ABR with DSP correction-Cambridge soundworks+Sunfire Subs

The HEOS also feeds Control4 for whole house

’best practice’ I said.

some audio shops roll each pair of speakers into a listening room so they are not exciting any others when you hear them.

yours in your space: play with both pairs adjacent as normal, fingers on the cones, any movement? then remove the inactive pair, any perceived difference?

If so, find a solution. If no perceived difference, you got lucky.