The amp's form factor is absolutely a big deal. My VAC 200iQs weigh 100 lbs each and it's just a box with absolutely no handles or grips. The distribution is very front loaded, where the transformers are. For proper front-to-back balance you have to slide your hands under just the RIGHT location a few inches back from the faceplate, or it will try to tip out of your hands and you're about to have a real bad time.
By comparison the Rogue Apollo is the exact same 100 lbs per side, but its chassis has built-in handles, and it's a more balanced distribution, and this effectively makes it "seem" around 30% lighter (or so). Fortunately tube amps don't have sharp heatsinks, but that could be a nightmare on some amps. My Phison A2.120 has very sharp edges but it's only ~ 50 lbs so not an issue.
My VAC 300iQ monos at least have some chassis structure (rails) that can be used as handles but I haven't tried to move them myself. 100lbs is my "safe limit" for just myself.
I highly recommend IronClad's Command Grip work gloves for moving heavy audio components.