I am really sensitive to high frequencies, have been since I was young. I’ve found speakers make a huge difference in listening fatigue, a ringing in my ears after a listening session. I think you have gotten some great advice on room treatments, using an EQ and the DAC. Even if you get that all “right” decent probability you’ll still need to address your speakers if they lean toward the brighter side. I’ve tried to take brighter speakers and while making changes to the room, electronics, using an EQ helped, didn’t solve the issue.
Soft Dome, silk tweeters along with various Ribbon tweeters paired with designs that trended toward a warmer, less analytical pull every drop of detail out of the music type speakers helped me out quite a bit, as much or more than any other change. Once I got the speakers right, the gains made through room treatment’s, electronics were enhanced verses masking the issue when I had brighter speakers.
I’d start with speakers so that you can then build around them when doing room treatments, making changes to electronics but you can also go the other way, do everything possible to make the speakers work and then swap them out but it’s a little like trying to modify an engine that isn’t really the best engine for the application to get it to work just good enough verses starting off with the right engine, then making modifications that only enhance the performance. I chased trying to make several different speakers work in my set up because they were highly regarded and with the right recordings sounded breathtaking, best advice I got along the way from Audio Dealers was that you can’t cable your way, electronic your way (DAC’s, Pre’s, Amps) around speakers that for whatever reason, fatigue, sound signature, aren’t a fit for you. Good News is that you have Mac gear, most of their gear is known for being more musical, less analytical, fatiguing, assuming the Mac already has their famous EQ settings, you have the right Pre / Amp to build around. If you treat the room a bit, even without a speaker change, you should notice a difference, drop the right speakers in and should be a noticeable improvement, tweak your DAC / Streamer and that should be the whip cream and cherry on the Ice Cream Sundae.
Good Luck!