I have heard some SET amps running the big transmitter tubes, including a 1610 tube, and I have not heard any that surpassed the lower powered SETs when playing speakers of high enough efficiency such that no amp was being forced to play out of their comfort zone. Yes, some 211, 845, 833 amps sound pretty good, but I still like the 45, 2a3, 300b amps a bit more.
I never ran my parallel SET 2a3 amp into hard clipping, but, I did suspect it was slightly compressing peak volume when playing certain kinds of music. This appeared when playing large acapella choral works at somewhat high volume--no obvious distortion but the music sort of stopped getting louder at peaks (99 db/w speakers).
I don't agree that, even with very efficient speakers, SET amps always win over pushpull. There are certain pushpull amps that deliver the same sort of natural, harmonically dense and complete sound of good SETs, while sounding a bit more punchy and dynamic. There are also contenders from a completely different camp--the output transformerless (OTL) amplifier. The incredible dynamics and liveliness of good OTL amps can be extremely captivating, and they deliver this kind of sound without necessarily being bright or harsh. I don't think any particular topology beats another; it is a matter of taste/priorities, system matching, and specific execution of the topology.