Agree completely with @erik_squires, @audiokinesis and others regarding treating the peaks with EQ, but not trying to boost nulls. Multiple subs helps with that (not wading into the swarm debate).
One tradeoff I have not seen explicitly mentioned (although @phusis hints at it), is that setting a higher crossover point gives you more freedom in placement of the speakers vs. placement of the subs. Leaving the issues of room treatments aside, place your speakers for the best soundstage and imaging, and place your subs to minimize the problems associated with the long wavelengths of low frequencies (which create both nulls and peaks).
Most room mode problems tend to occur with sub-125 Hz frequencies, although depending on room characteristics, they can go higher. But certainly, the lower you go, the more bothersome these tend to be. Flexibility of where you can place one or more subs helps tremendously. However, if you cross over at 35 Hz, for example, then you have pretty much lost that flexibility. You really can’t just move one of your main speakers 3 to 6 feet to deal with a peak at, say, 50 Hz, because moving them will ruin your soundstage. Crossing higher provides more options for sub placement to deal with troublesome modes.
So, up to a point, the higher you can cross over, the better, up until where you can start hearing the directionality of the subs. This is room-dependent and person-dependent, but typically is around 80 Hz. I experimented with 50 Hz to 80 Hz, and for my situation, crossing at 70 Hz sounded best.
The other issue sort of mentioned so far that could be stated more explicitly is phase-matching the mains and the subs at the point of crossover. This requires two things: (1) a continuous phase adjustment on the subs (like on those by Rythmik) or digital PEQ; and (2) a very steep and symmetrical crossover, typically implying an active crossover. That means both low-passing the sub and high-passing the mains are important. Because the wavelengths change quite a bit from 20 Hz (56 feet) to 80 Hz (14 feet), the mains and subs can only be in phase at a small range of frequencies. That is why the steep crossover is needed. Otherwise, even if the mains and subs are in phase at 70 Hz, with 6 dB/octave sloped filters there will be audible overlapping of the subs and mains from the lower audible limits all the way up to ~250 Hz or so. Because all filters have a frequency-dependent phase shift, most of that overlap is out of phase and contributing to "smudging" that translates to "slow bass."
For my Dali Epicon 6’s, what has worked well for me is an active crossover (24 dB/octave) crossing at 70 Hz to a pair of Rythmik F12G-SE’s with the GR-Research drivers. Mains about 7 feet apart works well for my space; the subs are in diagonally opposite corners of the room. Since I exclusively listen to digital, I can use Roon’s PEQ on a per-channel basis to remove the peaks from the room modes (almost entirely in the range the subs operate), and then careful placement allows each sub to fill in the other’s nulls. After the digital is converted to analog, I want to retain my Denafrips’ sound signature, so I don’t use digital PEQ involving more ADC and DAC conversions. Instead, I am using a Sublime K231 active crossover; the Burr-Brown op-amps used in it don’t seem to color the sound much.