VdH experimented with all sorts of strange insulation. Wood, ceramic beads, you name it. I’m not really a “wire guy”, being more on the side of proper gauge, quality insulation, straight runs, and making sure you don’t have a rats’ nest of touching/overlapping wires, or wires running close parallel, but instead crossing wire at 90 degrees
That said, the VdH interconnects would definitely impart a sound, or rather a tone, to the music. Kind of a tubey, warm, sound. Whether someone like that, is a mattter of taste.
Made me play with the idea that it is not so much the metal or metals in the wire that people are hearing, but that different metals interact with the insulating substrate differently.
That would finally make the wire fights people have make much more sense, as there is very little convincing science or testing to back up people’s claims.
But say, silver reacting differently to (name your insulation) than copper and getting a different result? Sure I could see that.