The big thing to confirm is the preamp under consideration has an auto-mute circuit, which triggers both for turn-on and turn-off, as well as brief power drop-outs. Not every preamp has a power management circuit that protects against all sources of transients. This is ESSENTIAL if you intend to mix a tube preamp with a transistor power amp.
Voltages over 20 to 50 volts will kill or degrade the input transistors, which are not designed for high voltages. A transistor power amp has no way of defending itself against transients of this magnitude ... I’ve yet to see a transistor power amp with an input relay. For that matter, coupling caps are quite rare in the transistor world. In any event, an input coupling cap will not protect the input section against a transient that large.
By contrast, a tube amp will tolerate a transient of hundreds of volts, even at the input. Not for long, of course, but for a few seconds, yes. To damage a tube amp the plate of the tube actually has to melt down, or more likely, burn up a cathode resistor. That takes time. By contrast, a transistor will fail from over-voltage or over-current in less than a millisecond, too fast to run across the room and turn it off. You’ll see a little puff of smoke emerge from the power amp and that will be it ... next step, a new circuit board with all-new parts. (I’ve seen this happen.)
There is no practical way to protect a transistor amp from what any manufacturer considers abuse (yes, the warranty will be voided, and yes, they can tell when the tech sees a burned circuit board with dead input transistors).
For better or worse, the burden of protection lies with the design of the preamp. Even transistor preamps can be the culprit if it has a split +/- 15 volt supply and one side folds down because it doesn’t feel like working any more (or if a regulator quits). That will yank the preamp output to either plus or minus 15 volts, it will stay there until repaired, and bye-bye power amp.
The real function of muting relay circuits is preventing these disasters. As mentioned earlier, output transformers can also prevent DC from getting through, and DC transients don’t make it through, either, because the transformer rejects all signals below 14 to 20 Hz.
Direct coupling has many advantages, but unfortunately, failure modes can propagate through the entire electronics chain unless protective measures are taken.