In an office with a desk and a lot of reflective surfaces having the speakers behind you is a great way to listen. I have been doing that for a decade. See my Office system on Virtual Sytems page. What is posted is my old office.
I just sold my Magnepan LRS+, but that speaker works great in a small room since it has a more direct projection of the sound, less reflections.
My new space is smaller, so I bought the Magnepan Mini 2 days ago. It will be excellent in the space I have now.
If you have a room that is at least 12 x 11 x 9 then a lot of small speakers will work in that space behind, you. A KEF LS50 Meta is another great choice. I had that before the LRS+
In all of these setups I used the excellent KEF KC62 sub.
For my Magnepans I use a lot of power such as the Sanders Magtech amp.
In my old office I had 6 computer monitors. In my new space I have 10 monitors. Got great sound in the old and expect great sound with the Magnepan Mini's in the new space.