Yes. When I added Iconoclast Series 2 TPC speaker cables, the upgrade was dramatic. My boss called out from 2 rooms away to tell me that whatever I did, the system sounded much better. Later, she even turned the system on herself to sit and listen, which is rare. And the true test: She didn't start by asking "how much did it cost?" After she approved, I nervously asked if she wanted to know the cost. She said "no, it was worth it for that kind of improvement". (!!!)
Another big cable improvement was the Tubulus Concentus v.2 I2S cable btwn. my Jay's transport and PS Audio Stellar Gold DAC. Sublime!