I went through a similar analysis a couple of years ago. I had Serafinos and was looking to upgrade to the Amati. Both are great speakers and I have a fairly large room as you do. The Amati Filled the room better, and I thought gave you a little more of everything over the smaller Serafinos.
I had a chance to audition the Il Cremonese And I thought it was at a different level. Not just a larger speaker, with a significant jump in sound quality. Better bass control, more dynamic, and bigger soundstage. I bought the Il Cremonese and I’ve been very satisfied. if you like the SF sound, I don’t think you can go wrong here, all are great speakers, but worth giving a listen to the reference level, particularly for a room your size