If possible, use as little anti-skate as you can. Every cartridge/arm combo will yield a different percentage of your VTF. I have various arms and cartridges and have found a good approximation which falls between 25%-30% of your VTF. Dial it in and go from there.
Anti-skate cannot be accurately set so don't be obsessed with it. Anti-skate at any different point on a record is different. Different records require different amount of anti-skate. IMO, set it up once and leave it unless you're in the camp of tweakers who set it differently on various LP's to maximize sonics. Nothing wrong with this but takes a lot more effort.
What you have to do is just relax and listen.