Chris, yes I suggested to Doug S that he try it on the last bi-wiring thread. It's as safe as leaving both straps in, which is safe as long as you dont cross positive and negative. Jon Risch, who recommends trying it says its system dependent and may or may not yield any benefit.
I think the majority of people who have tried it have said it sounds better that way, more detail. A few have said it makes no diff, and a few (like me) say it's worse. I notice a real difference in frequency response, almost as though the tweeter output is boosted with the one strap in, and subjectively, there's less bass. That is consistent with reports by others of greater detail and more air, but as to whether that is "better" is a matter of opinion. Seems like a modification to the speaker's design, which I would not want to with my speakers.