Will a quality USB cable make a difference....

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It is obvious that the first 2 responders don't have the system or savvy to hear the difference.

Just kidding, like was pointed out above, you will never get the answer you seek by asking that question. When you ask these cables questions, if you get enough responses, some will respond that they hear huge differences and some will say they hear none. That means the only way to tell is to try it yourself which basically means all threads of this type are worthless except as a means to waste a little more time on these forums.

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Don't agree. I went from a 35.00 USB that came with my HRT Music streamer to a more expensive WireWorld USM and found a pretty big difference. Much smoother and fuller sound. I could not beleive it my self. The Wire World StarLight is a nice cable design. YMMV

I completely agree with Ml8764ag on this. I hear differences in almost ALL cables and tweaks, and have a system capable of showing off the tiniest differences. But I can not hear any difference in my cheap Belden Gold USB cable and the much more expensive Wireworld Starlight USB cable ... Save your money.

This is between a drive and computer. Most claim no difference in this application. I would be more concerned with using a USB drive w/ a USB DAC, if indeed you are...

I've spent a small fortune on interconnects and speaker wires and do think I appreciate good cables. I agree on the DAC comment as well. I didn't try the Wire World product but did try Cardas, Kimber and Audioquest and could not hear any difference between those and what came with my Mac.

Just my two cents. I can think of a dozen better (more Pareto optimal) uses for the money just in terms of tweaks and the like.