Generally if there is an audible difference then a difference can be measured. Specifications are however measured under conditions that are not typical of when a power amplifier is used to drive a complex load (speaker).....hence the possibility for different sound. In general, good pre-amps should sound exactly the same - if they sound different then one may be suspect or there is a mismatch between rated input and output levels and/or impedance with other connected components. Often a distinguishing feature between a good preamp and an excellent one is better channel separation, immunity to noise (from dirty power) and lower noise floor.
Note that the other way round is not true....often a difference can be measured that is inaudible when listening to music.
Note that the other way round is not true....often a difference can be measured that is inaudible when listening to music.