Not to say it cannot be done, but I have yet to hear a SET amp do rock/pop well, at least on the usual terms of rock/pop music which is different than much classical, jazz.
At shows, when SETs and high efficiency horns have been featured, the demos are always jazz or classical.
At Capital Audio fest, after hearing some nice sounding Jazz being played, I asked to hear some Rush on vinyl in the Zu room where their larger high efficiency speakers were being demoed on a 5-6 watt tube amp. It sounded nice enough in a polite sort of way, but much lacking on any kind of muscle or drive needed for that kind of music. The ZU guy admitted more power was needed really for that.
So I am thinking it may be possible, but certainly much more of a challenge than other approaches perhaps. I just have not heard it yet, though I am sure I have not "heard it all" yet regarding SETS/hi eff. speakers.
THough no rock music was played, I felt like the Atmasphere/Classic Audio combo at teh same show could have done it nicely, but that was a much more powerful tube amp being used, not a SET.