While I agree that its better to have nothing between or behind the speakers, I've had less negative impact in a larger room, with speakers positioned relatively further into the room. IOW, if there's still plenty of air between and behind the speakers, it isn't quite as problematic as the same setup in a smaller room.
One point worth addressing when you place gear on a side wall; don't place a turntable at the primary reflection point, or you risk creating a feedback problem. Ideally, you would want room treatments at that spot anyway. Cheers,
Spencer