I am a big fan of the 45 tube. I have heard it used in parallel single-ended, pushpull (I own a pushpull 45 amp) and in single output tube single-ended configuration. It delivers a very punchy, clear and detailed sound when operated well within its upper output limit.
I think someone can effectively utilize a 45 SET amp with the AN-Es in a smaller room, provided that one accepts that it will not be able to play at high volume levels. I am quite familiar with the AN-E and I have heard it with some fairly low-powered amps; a local dealer frequently pairs the AN-E with an Audio Note Kageki amp which is rated at 6.5 wpc. I can hear the limitations of this amp when playing demanding music, such as large choral pieces. The music begins to suffer from compression and becomes muddled and unfocussed to a slight degree. But, these are problems I can see someone living with because, for the VAST majority of the time, a good 45 amp will sound great.
I do agree with Atmasphere that a 45 SET is really best used with extremely high efficiency horn systems. A friend had such an amp for his107 db/w system and it sounded great. That kind of combination can be recommended without much reservations; the use of a 45 SET with something like the AN-E can only be recommended with the caveat about limited volume levels.