I have never failed to hear a difference with any wire -- power cords, interconnects, speaker, digital -- that I changed in any system I owned. Sometimes that difference was subtle, more often it was the indisputable. All my audiophile friends agree on the charterization of these differences. On the other hand, in my 75 years on the planet, I have met many people with tin ears and many people and closed minds. Nonetheless, I suppose there are systems that are impervious to such changes, although I have yet to encounter any.