I think it really depends on your source and DAC. I have an Auralic Aries G2 server going into the DAC built into my NAD M12 DAC/Preamp. It’s a decent DAC - not great - but pretty decent. There’s reason to believe that newer high DACs are moving in the direction of USB and Ethernet being the preferred connection.
I had my server hooked up via a Nordost Heimdahl digital cable (1.5M). It was superior to the Audioquest digital cable I previously had (don’t remember model but it was probably $300 when I bought it). However, based on another thread, I thought I should try the USB connection and bought a Nordost USB cable (much less than the Nordost SPDIF/Coax cable). And, it’s a bit better than the SPDIF connection. Not loads better, but a bit more depth and openness. Now I may try the Nordost Heimdahl USB cable. (Where does it end...).
I know an Aurender dealer who prefers the USB connection on his N10 going into his DAC. YMMV.
So, I think the only way to know is to audition it yourself. It seems to me to be very system dependent.
Best,