I’ve played with different transmission types and they all have there pros and cons and work well. USB is fine from my experience. Like to OP I had a Innuos.... Zen and Zenith in my system. (Ended up keeping the Zenith) I’ve A/B’d many cables from Inakustic, Qudioquest, Acoustic BBQ, Ocelia, Cardas and they all worked without a hiccup in either and Aqua or Ayre DAC.
Might the OP have a faulty port at one end?
Might the OP have a faulty port at one end?