What sends shivers down your spine when you play it on your system?

Art Pepper “Patricia” long version
Brubdck Quartet “Blue Rhondo” carnigie hall version 
John Coletrain “Summertime”
Sonny Stitt “Cleveland Blues”
Dr Lonnie Smith  “Backtrack”
...............

Oxygène.   the sound just swirls all around me, like i am a mote in the eddies.

First one that comes to mind is the saxophone on Morphine's 'All Your Way' 

Oh, there’s a bunch... but stand outs:

White Rabbit: Jefferson Airplane original vinyl
Time Out: mono version. (Whole album)
Camera Eye: Rush
Pretty much anything Pink Floyd

Lot’s of EDM gets it too. Many others...

1812 Overture - London Symphony Orchestra - possibly the most emotional piece of music ever written.