I don't have Node 2i, but in general you only send data (in packets) over WiFi or Ethernet. As long as data sent is the same - sound quality should be the same. If anything, WiFi should be better, since Ethernet can inject electrical noise (in spite of galvanic isolation in Ethernet standard).
I had dropouts with WiFi, but it is perfect now, after switching to 5GHz.
I had dropouts with WiFi, but it is perfect now, after switching to 5GHz.