There is an excellent article on this question written by Geoffrey Morrison in Wire Cutter. It’s called: "The Best Speaker Cable". Google it. It’s written from a scientific perspective (i.e. data; measurements; double-blind auditions; etc.). This article features a bunch of additional links to other articles regarding interconnect cables and testing procedures involved. I found it extremely interesting, authoritative and informative. It also corroborates my own experiences in this regard. For speaker (and other audio) cables, it comes down to this: as long as you’re comparing cables or wires, reasonably well manufactured of quality materials, under controlled critical listening trials, length and guage are what matter most. For example: given a 6’ pair of reasonably good speaker cables, will most people be able to hear the difference(s) between 16 AWG and 12 AWG cables or wires in casual listening? Most probably won’t. Will they be able to hear the difference(s) in critical listening? Some will; some won’t. Will bona fide audiophiles be able to hear the difference(s)? Quite likely. Will that difference(s) be profound? No, unless you want to ascribe a subjective definition to the word "profound". Will a $150.00 pair of good 12 AWG cables sound different than a pair of $10,000.00 12 AWG cables to the average listener in critical listening trials? Very likely not. Will the same cables sound different to bona fide audiophiles in critical listening trials? Some may hear a difference(s); some won’t. Will those audiophiles who think they can hear a difference(s) perceive that difference(s) as better or just different. Well, "better" is in the ear of the beholder but, basically, it’s really just a difference(s); not demonstrably better, per se. At this point, any perceived differences are subtle and minute in the extreme and no one will be able to convince an audiophile who has spent $10,000.00 on speaker or other cables that s/he could have spent a tenth of that or less to achieve, effectively, the same results!