Depends what the tubes are doing. Parallel triodes, SRPP or cascode configuration, or voltage regulation or constant current sources. It's likely more will sound better but not definite.
While we often crave one dimensional solutions to simplify our lives, it's not possible to land at any conclusion on SQ based on the number of tubes in a preamp. It's all about the implementation.
Just for a different perspective...designs that are using 8 preamp tubes most likely are the more expensive preamps but no idea if that relates directly to sound quality. There are some good tube preamps with just two tubes.
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