$50k - $80k Budget…Opinions please.

Here's what I'd consider

Speakers: SF Olympica Nova 5 (~$20k)

Amplification: Moon 860Av2 (~$20k)

Preamp/Network combo: Moon 390 (~7k)..the new 791 (~$16k) could be interesting

Roon Nucleus with internal hard drive (~$2k)

If desired turntable with isolation platform (e.g. Rega P8 {~$5}  with HRS platform {$1,5k})

Speaker cables ($2k), interconnects ($2K) and power cables with power distributer ($3k) with circuit guard (Shunyata power, Nordost/Transparent/Kimber speaker cables & interconnects)

Audio rack (~$2k)

Stressless Recliner ($3k)

But that's me...

With that budget you should be able to go digital only and rival many analog systems.

I’d spend most of my time and budget on the finest pair of speakers that floats my boat and works with my room and whatever treatments it will have. Then would pursue proper amplification for them with the features you want. It’s too subjective and proprietary to your situation to make specific recommendations, but odds are good it’ll be brands that the main stream aren’t overly familiar with. I'm partial to good tube electronics and/or tube/SS hybrid bi-amp situations, and great midrange with clarity and convincing soundstage...your tastes may vary, but there's no reason to settle for anything you don't love. 

Select music sources and cabling that will play well with the speakers and amplification, and that you’ll be happy using.

You’re smart to be planning in advance.

With that budget you need to demo. If you want to buy new and could find a dealer that you could buy everything from I bet you could get a Substantial discount. 
 

Them prices I would be looking at Higher end Focals but that’s just my tastes. 

@toddcowles I never would have guessed that there’s another soul on this planet who loves both Radiohead and Brent Cobb…good luck w your system!