Will one cable upgrade make a noticeable difference?

My system is pretty set cable-wise with mostly Transparent Ge5 Ultra SC, Ref PCs, FTA SINOPE USB, SOtM dCBL CAT 7 and and Transparent Ethernet on my major components. Also some Wywires and Wireworld mid-level PCs on Innuous PhNet and PhUSB and REL sub.

The only “legacy” cable is a Synergistic Research Element Copper RCA between my Chord DAVE and Pathos Heritage MKii integrated.

Question: Would replacing the SR with either a Transparent G5 Reference or G6 Ultra make a noticeable difference in the sound?

Or other suggestions? Budget approx $1500 on used market. TIA and happy listening.

Pathos Heritage MKii integrated

Innuos Zenith MK3 * Ph’NET and Ph’ USB

Audiowise OPTO DX

Transparent G5 PowerIsolator

CHORD DAVE w/ Sean Jacobs LPS

M Scaler w/ Teddy Pardo LPS

REL S/812

Tannoy Kensington GRs