FWIW, which may be very little, I had a negative reaction to a pair of Purist Audio Design Aqueous 20th Anniversary speaker cables that I purchased (and quickly re-sold) on the used market. It may have had something to do with system, but I went back to Audience cables, which had been my choice for years.
I was using a (high-quality) GATO integrated amp, and Harbeth 30.1 speakers.
I frankly can't recall the details, but I know that I much preferred the Audience AU24e that I had used previously.