The usual suspects of the hallucinogens can make a listening session more interesting, or disturbing, or pleasurable..... but, by far, the most engaging substance to listen to SOME music on is Salvia Divinorum and consider that to be true with the higher powered extracts (30X and stronger). Pure leaf and weaker extracts won't take you there. The duration is only about 10 minutes but your immersion in the music and the world it creates is almost total in that you experience a complete vision, not an alteration of the place you are in. Your listening room will disappear to be replaced by an altogether different location. Select your music wisely for positive results. I've had my best experiences with the more tribal offerings of Steve Roach. Pushing the envelope, Randy Greif's cd "Verdi's Requiem" is mind-blowing but potentially frightening for the inexperienced. I've avoided other genres so can't comment on them. Just my 2 cents....