odd question about stand-mount speakers

don't forget d'appolito design

 midwoofer-tweeter-midwoofer loudspeaker configuration (called MTM, for short)

https://en.wikipedia.org/wiki/Midwoofer-tweeter-midwoofer

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my office, real bookshelf speakers (fit on 11-1/2" deep shelf, no rear or side ports)

vertical tweeter at seated ear height. horizontal, tradition says tweeters to the inside due to narrower dispersion of tweeters. 

Both prior Wharfedale's and current restored AR-2ax (horizontal) sound better with the tweeters to the outside. Every space is different.

Yes, a d'appolito design would accomplish the same thing. Plus I wouldn't have to upend the speakers, and the mids/lows would be spread out over two drivers instead of one (per channel), potentially enhancing the sound quality. The only drawback is there are a lot more MT design stand-mounts to choose from than there are d'appolito designs.

I’d focus on monitors that are designed that way unless you can arrange an in-home trial of one where the tweeter was designed to operate above the midwoof.  FWIW.

No harm in trying it out.

It depends on how the crossover was designed and it's affect on vertical dispersion and interaction between the 2 drivers. The dispersion won't be the same upside down and a good speaker was designed to be used the way the designer tells you.