Peter Lederman in Second Bout With COVID-19
@stringreen You would rather have the do nothing Twitter tool, who is a thin skinned narcissistic egomaniacal chaos creating clown than someone who is getting the job done? Granted, in a country with a population in excess of 330 million people, you would hope they could find someone better to choose from than a lying conman and someone who should have retired by now. |
thankful, Sorry for my feeble attempt at humor. If you will take the time to access the information that is publicly available, perhaps you will ameliorate your fears, if I am correct in assuming that you are "cautious" about getting vaccinated. This particular thread started out with COVID as its subject in the first place. I apologize to anyone who is offended by the persistent theme perhaps abetted by me. Like Michael Corleone, I tried to get out of it in order to honor the expressed wishes of PL, but they kept pulling me back in. Meantime, tomic that is a terrible story. My condolences. |
How did the virus escape? Accident or intentional? Remember we are dealing with the CCP who have a plan to dominate the world by 2048 and have great control in our nation (don't doubt it). OK, but that has nothing to do with the crux of the debate which is about the safety and efficacy of the vaccines without a doubt we were lied to Jan 22, 2020 "We have it totally under control. It’s one person coming in from China. It’s going to be just fine.” Feb 10, 2020 “Looks like by April, you know in theory when it gets a little warmer, it miraculously goes away.” Feb 24, 2020 “The Coronavirus is very much under control in the USA… the Stock Market starting to look very good to me!” Feb 25, 2020 "I think that's a problem that’s going to go away… They have studied it. They know very much. In fact, we’re very close to a vaccine.” Feb. 26, 2020 “The 15 (cases in the US) within a couple of days is going to be down to close to zero.” Feb. 26, 2020 “We're going very substantially down, not up.” Feb. 26, 2020 “Well, we're testing everybody that we need to test. And we're finding very little problem. Very little problem.” Feb. 26, 2020 "This is a flu. This is like a flu." Feb. 27, 2020 “It’s going to disappear. One day, it’s like a miracle, it will disappear.” March 6, 2020 "I think we’re doing a really good job in this country at keeping it down… a tremendous job at keeping it down.” March 6, 2020 “You have to be calm. It’ll go away.” March 8, 2020 “We have a perfectly coordinated and fine-tuned plan at the White House for our attack on CoronaVirus.” March 13, 2020 “I don’t take responsibility at all.” |
This is an interesting conversation. I have doctors in my family and friends who work in labs to consult. But at the end of the day there are still several important questions that need to be answered. How did the virus escape? Accident or intentional? Remember we are dealing with the CCP who have a plan to dominate the world by 2048 and have great control in our nation (don't doubt it). Was it used for any nafarious purposes? Was there misinformation fed to the masses? Were the views of many doctors censored? Did it invoke fear? Fear is a powerful emotion that can be used to control a society. How can we look at the last several years in America and trust anything we are told??? |
So I view the success of the Moderna and Pfizer vaccines as nothing short of a miracle. But it is not magic; there is solid science behind the unprecedented success of these particular RNAs. Most lay people cannot and do not appreciate how lucky we are that advanced thinking bore such fruit.Well said Lewm. I am glad to have common ground with you on this topic. which btw is utterly bizarre under "analogue". It belongs under "digital" or at least "tech talk". |
Interesting how someone - who works at the 2nd largest hospital - does not give up their credentials... millercarbon9,927 posts
https://forum.audiogon.com/discussions/technical-sophistication/by_member?username=millercarbon |
I have 45 years experience as an MD/scientist with a research interest in certain human pathogenic viruses and vaccine development, both on the developer side and on the reviewer side. I retired 2 years too early to have been involved in the fight against COVID. Based on the past 20+ year history of using RNA in a vaccine, all unsuccessful, and on what was known a priori about Coronavirus immunology, I was very skeptical about the eventual utility of an RNA vaccine in preventing COVID and particularly about the longevity of the immune response one might expect from an RNA vaccine, even if there were short term protection. So I view the success of the Moderna and Pfizer vaccines as nothing short of a miracle. But it is not magic; there is solid science behind the unprecedented success of these particular RNAs. Most lay people cannot and do not appreciate how lucky we are that advanced thinking bore such fruit. Only a very few licensed vaccines achieve 95% or better efficacy in preventing disease. Think where we would be now and for the indefinite future, if the current vaccines were failing. That is why I am continually dismayed by the doubters and conspiracy theorists, although I do understand that some may be put off by the reports of side effects. What is almost never mentioned in the press is the rarity and transitory nature of these events and the fact that there are treatments and preventatives available. |
As an audiophile with more to learn than contribute at this point in my development, I mostly lurk on these pages. I hope to be more of an accurate contributor soon. That said, I am certain that there are hundreds more like me reading posts by ignorant blowhards with advanced Dunning-Kruger spreading lies about covid and vaccines, and shaking our collective heads in disgust. I’m looking at you miller carbon. |
Dr. Desch, MnMark, ediver, and Lewm... thank you all for your professional, expert, opinions. I am NOT a virologist, MD, clinician, et all, But, I listen to experts! My own experience - I had covid - it was not that bad when I did. I did loose taste and smell. I was fatigued. My nose was stuffy. But, I would compare it to a sinus infection. For others, it's fatal. I was lucky. My first shot sucked and that's actually when I had the worst vaccine side effects, the second shot was a breeze. (Both times, my arm felt like I had been hit by a 100 mph baseball. The shots were nothing - ZERO pain - but for a few days after, each time, my arm was killing me. But overall, I was fine! And, I would rather have that than covid again) That is my anecdotal experience. Others, as with all people, will be different. I don't know if any of you were on the front lines, but our country tends to applaud fire and police. But the truth is, Doctors, experts, are the real heros in this country. A cop might save 1 or 2 people in the course of his / her career, a doctor, saves thousands in that same time. Keep your chins up - and please know, you're very appreciated. |
I live in Washington DC. Covid cases peaked at the beginning of 2021. Deaths peaked in May 2020 with a secondary peak at the beginning of 2021. The Pfizer and Moderna vaccines became available in Washington DC at the beginning of 2021. Currently 53% of DC residents are fully vaccinated and another 10% have received one dose. The result? Only a handful of cases and no deaths. DC even vaccinates people in their homes if necessary. |
There is not much one can do over the internet when people decide that their chosen alternate reality is real despite all the evidence to the contrary one encounters in the real world. Pandemics, elections, vaccines, doesn’t matter until reality intercedes somehow. Anything to make one feel special I suppose. Mind games. |
@aj523, Can you please provide an update regarding your new Hyperion by Soundsmith in one of the Hyperion posts? If you could also include quick overview of your system that would be great too. I am interested to hear your feedback. Since I joined the Hyperion club late last year I don’t think many others have acquired one of these specialty built cartridges by the man himself. Thank you. Ciao, Audioquest4life |
Thanks @mnmark very well said. I'll also mention that the NYT had an interesting article yesterday about the evidence for and against SARS-COV2 being released as a lab accident rather than direct Bat to human transmission. Still lots of questions. But there is no question that the mRNA vaccines are safe and useful at preventing Covid-19 disease. I feel lucky to have had access to them in December and now my entire family is fully immunized. Also, I love my SoundSmith Sussurro! Full disclosure... Karl Desch, M.D., Associate Professor of Pediatrics, Neonatal-Perinatal Medicine, Cell and Molecular Biology Program, University of Michigan. |
MC, please see the attached; this virus has a polyphasic cleavage site of 5 arginines (furin substrate), and two are encoded by CGG. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC391999/pdf/pnas00622-0148.pdf |
I had covid in March of 2020. Two months later I developed heart palpitations. About 50-60 times a day it felt like my heart stopped. Of course I had the luck of good medical care and determined they weren’t life threatening. Two weeks after my second shot they stopped and I haven’t had a heart palpitation since. |
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Interesting how someone - who works at the 2nd largest hospital - does not give up their credentials… Because in their own minds, there is nothing they are not an expert in. In reality, they should stick to discussions on isolation devices etc. There are also line cooks who work at the same hospital. I would no more want their thoughts on how to prepare a sous-vide steak and what wine would go well with it if served with white asparagus than I would want to know their thoughts on the efficacy of vaccines for CV19. It’s sad how some you would think should have a rational outlook on the complexities of life, but no. Frail egos do not allow for that. It’s also dangerous, the useless and false vitriol spewing from their keyboard. Sad. |
There is no point in debating this topic with those who have drunk the kool-aid. They view the truth as lies, and visa-versa. Now THERE is a condition that is hard to treat. It’s a shame John Prine didn’t know this talk of a Covid pandemic was a hoax, a liberal conspiracy to, what, make money and rule the world? How embarrassing it's going to be when they finally realize they were played for patsies, real suckers. |
I have tried my best to stay out of this fray, but after reading several of the recent posts from the past 48 hours, I feel obligated to clarify several pieces of “information” that have been posted as factual before they get deleted like the infamous “no excess deaths” post. Though the risks of death to individuals under the age of 40 is very low, the risk of hospitalization and the associated costs remain quite significant. If you can remember back in about February, the vaccine was first offered or “pushed” if you prefer, to those who were the most at risk, including the aged, health care workers, and those with underlying conditions. Only now that most from the first groups are vaccinated, it is being “pushed” to the less susceptible younger age groups because they are more reluctant to get vaccinated. Though they might get a milder case of Covid19, they will be spreading it to older and more susceptible individuals while they are infected. The vaccines work remarkably well. The idea that the vaccine is causing increased cases of Covid19 is drivel. By all accounts, Wikipedia, Oxford, Merriam-Webster, an mRNA vaccine is a vaccine – a biological preparation used to elicit an immune response, and is listed as such. To claim otherwise is nonsense. As long as I can remember, following a vaccination of any type, I have been asked to wait for a period of time for observation purposes. It said so on all the vaccine info sheets. The problems of developing a vaccine for HIV have been addressed in an earlier post with a very appropriate link. The rapidity with which the Covid19 vaccines were developed is more a testament to the advancement in medical scientific research and the promise of mRNA vaccine technology, than a commentary on economic drive. The amino acid sequence CGG-CGG is not an amino acid sequence at all, and would not be identified as such by anyone with even a rudimentary understanding of cell biology. C and G are nucleotide bases, and when arranged as these two triplets, code for a repeat of the amino acid arginine. The nucleotide sequence CGGCGG in fact does occur in nature and is a part of the nucleic acid sequence of fragile X syndrome (FMR1) gene of human origin. In January 2021, a publication found over 6101 unique CGG polymorphic repeats in a study of 544 human whole genomes analyzed. But, I digress. I suspect that the claim mentioned was misconstrued somewhere along the line by someone not understanding the details of a recent article (June 8th) in the WSJ or one of the many other rehash articles, which state that CGGCGG is not found in any other naturally occurring Coronavirus. A researcher would be hard pressed to publish a gene function paper in any peer reviewed journal in the fields of cell biology, molecular biology, biochemistry, etc. without doing appropriate gain-of-function and corresponding loss-of function studies. They are conducted in all major public and private institutions that have labs that compete for government funding and publications. There is nothing sinister about modifying, inhibiting, or adding a gene to a virus, an organism or a cell line to see if it responds as predicted to advance worthwhile understanding. In the case of a virus capable of infecting humans, these studies can demonstrate how the virus binds to human cells, what receptors or cell surface markers, or conversely what viral spike proteins might be involved and how the process might be inhibited. The linked article about the CDC getting caught red handed changing the thresholds of positivity as though it is something nefarious, even states that the changes were described on the CDC website. If one were to just check, the rational for doing so is clear and is described in a pertinent post above. In short, many of the posts above are not close to being factual, or at best, represent one-off anecdotal occurrences. Many come from right wing conspiracy theory and outrageous claim clickbait sites. I expect better. |
@retipper I am so glad you are recovering. Like @lewm I agree that even a single vaccination appears to protect those who have had SARS-CoV infections, and in cases of long haul COVID, sometimes largely ease lingering symptoms. Please continue to heal, and I also appreciate your poetry. Please let us know if there is anything we can do, in addition to buying and promulgating Soundsmith. @lewm I also used to be a molecular virologist (flu virus lab). Thank you for replying, esp. to MC, and others who might believe his claptrap. Remarkably, both mRNA vaccines have been shown to be at least partially effective against the delta variant, even though that variant wasn't around when the vaccines were designed. Newer pre-prints claim to show that vaccine induced immunity may be effective for several years. A remarkable job by many, and regardless of the viral origins, there's the undisputed fact that China should have realized what was going on with the outbreak (or did and covered up), and notified the world much earlier. Then perhaps a travel ban down may have proven effective, as was done for MERS and SARS initially. The problem with SARS-CoV is that the symptoms occur so much longer after infection, and mimic other conditions for a while... @millercarbon Please stop spouting this nonsense. You do everyone a grave disservice. You appear to be trolling, and didn't bother to spell whether correctly, so it appears you put little thought into your posts. |
Again, the amino acid sequence CGG-CGG occurs nowhere in nature. It is however used in gain of function research. And it is found in the CCP virus. Furin cleavage sites on the CCP virus enable it to enter human cells. This virus, which fake news tells us came from a bat, has amino acid sequences found in no bat virus, and it has a greater affinity for human cells than bat. The nonsense we have been fed, that many of you so strangely want to believe, is demonstrably false. Does anyone even know what I'm talking about? Cytosine? Anyone? Beuller? |
Meanwhile elsewhere... https://www.nytimes.com/interactive/2020/health/oxford-astrazeneca-covid-19-vaccine.html |
